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Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway.

Cell death discovery

Lam T, Harmancey R, Vasquez H, Gilbert B, Patel N, Hariharan V, Lee A, Covey M, Taegtmeyer H.
PMID: 27625792
Cell Death Discov. 2016 Aug 22;2:16061. doi: 10.1038/cddiscovery.2016.61. eCollection 2016.

We have previously observed the reversal of lipid droplet deposition in skeletal muscle of morbidly obese patients following bariatric surgery. We now investigated whether activation of autophagy is the mechanism underlying this observation. For this purpose, we incubated rat...

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Lam T, Harmancey R, Vasquez H, et al. Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway. Cell Death Discov. 2016;2:16061doi: 10.1038/cddiscovery.2016.61.
Lam, T., Harmancey, R., Vasquez, H., Gilbert, B., Patel, N., Hariharan, V., Lee, A., Covey, M., & Taegtmeyer, H. (2016). Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway. Cell death discovery, 216061. https://doi.org/10.1038/cddiscovery.2016.61
Lam, T, et al. "Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway." Cell death discovery vol. 2 (2016): 16061. doi: https://doi.org/10.1038/cddiscovery.2016.61
Lam T, Harmancey R, Vasquez H, Gilbert B, Patel N, Hariharan V, Lee A, Covey M, Taegtmeyer H. Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway. Cell Death Discov. 2016 Aug 22;2:16061. doi: 10.1038/cddiscovery.2016.61. eCollection 2016. PMID: 27625792; PMCID: PMC4993124.
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Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells.

Cell death discovery

Jinesh GG, Kamat AM.
PMID: 27226900
Cell Death Discov. 2016;2. doi: 10.1038/cddiscovery.2015.69. Epub 2016 Jan 25.

The blebbishield emergency program helps to resurrect apoptotic cancer stem cells (CSCs) themselves. Understanding the mechanisms behind this program is essential to block resurrection of CSCs during cancer therapy. Here we demonstrate that endocytosis drives serpentine filopodia to construct...

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Jinesh GG, Kamat AM. Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells. Cell Death Discov. 2016;2doi: 10.1038/cddiscovery.2015.69.
Jinesh, G. G., & Kamat, A. M. (2016). Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells. Cell death discovery, 2. https://doi.org/10.1038/cddiscovery.2015.69
Jinesh, Goodwin G, and Kamat, Ashish M. "Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells." Cell death discovery vol. 2 (2016). doi: https://doi.org/10.1038/cddiscovery.2015.69
Jinesh GG, Kamat AM. Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells. Cell Death Discov. 2016;2. doi: 10.1038/cddiscovery.2015.69. Epub 2016 Jan 25. PMID: 27226900; PMCID: PMC4876976.
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Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak.

Cell death discovery

Megyesi J, Tarcsafalvi A, Seng N, Hodeify R, Price PM.
PMID: 27226901
Cell Death Discov. 2016;2. doi: 10.1038/cddiscovery.2015.66. Epub 2016 Jan 18.

Apoptosis is a regulated form of cell death that proceeds by defined biochemical pathways. Most apoptosis is controlled by interactions between pro-survival and pro-apoptotic Bcl-2 family proteins in which death is often the consequence of permeabilization of the mitochondrial...

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Megyesi J, Tarcsafalvi A, Seng N, et al. Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discov. 2016;2doi: 10.1038/cddiscovery.2015.66.
Megyesi, J., Tarcsafalvi, A., Seng, N., Hodeify, R., & Price, P. M. (2016). Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell death discovery, 2. https://doi.org/10.1038/cddiscovery.2015.66
Megyesi, J, et al. "Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak." Cell death discovery vol. 2 (2016). doi: https://doi.org/10.1038/cddiscovery.2015.66
Megyesi J, Tarcsafalvi A, Seng N, Hodeify R, Price PM. Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discov. 2016;2. doi: 10.1038/cddiscovery.2015.66. Epub 2016 Jan 18. PMID: 27226901; PMCID: PMC4877050.
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iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

Cell death discovery

Ullah M, Kuroda Y, Bartosh TJ, Liu F, Zhao Q, Gregory C, Reger R, Xu J, Lee RH, Prockop DJ.
PMID: 28179988
Cell Death Discov. 2017 Feb 06;3:16064. doi: 10.1038/cddiscovery.2016.64. eCollection 2017.

One attractive strategy to treat cancers is to deliver an exogenous enzyme that will convert a non-toxic compound to a highly toxic derivative. The strategy was tested with viral vectors but was disappointing because the efficiency of transduction into...

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Ullah M, Kuroda Y, Bartosh TJ, et al. iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell Death Discov. 2017;3:16064doi: 10.1038/cddiscovery.2016.64.
Ullah, M., Kuroda, Y., Bartosh, T. J., Liu, F., Zhao, Q., Gregory, C., Reger, R., Xu, J., Lee, R. H., & Prockop, D. J. (2017). iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell death discovery, 316064. https://doi.org/10.1038/cddiscovery.2016.64
Ullah, M, et al. "iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers." Cell death discovery vol. 3 (2017): 16064. doi: https://doi.org/10.1038/cddiscovery.2016.64
Ullah M, Kuroda Y, Bartosh TJ, Liu F, Zhao Q, Gregory C, Reger R, Xu J, Lee RH, Prockop DJ. iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell Death Discov. 2017 Feb 06;3:16064. doi: 10.1038/cddiscovery.2016.64. eCollection 2017. PMID: 28179988; PMCID: PMC5292869.
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Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks.

Cell death discovery

Ishii M, Rohrer B.
PMID: 28179989
Cell Death Discov. 2017 Feb 06;3:16071. doi: 10.1038/cddiscovery.2016.71. eCollection 2017.

'Bystander effect' refers to the induction of biological effects in cells not directly targeted. The retinal pigment epithelium consists of hexagonal cells, forming a monolayer interconnected by gap junctions (GJs). Oxidative stress initiated in an individual cell by photostimulation...

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Ishii M, Rohrer B. Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks. Cell Death Discov. 2017;3:16071doi: 10.1038/cddiscovery.2016.71.
Ishii, M., & Rohrer, B. (2017). Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks. Cell death discovery, 316071. https://doi.org/10.1038/cddiscovery.2016.71
Ishii, Masaaki, and Rohrer, Bärbel. "Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks." Cell death discovery vol. 3 (2017): 16071. doi: https://doi.org/10.1038/cddiscovery.2016.71
Ishii M, Rohrer B. Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks. Cell Death Discov. 2017 Feb 06;3:16071. doi: 10.1038/cddiscovery.2016.71. eCollection 2017. PMID: 28179989; PMCID: PMC5292780.
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A homolog of cyclophilin D is expressed in .

Cell death discovery

Bustos PL, Volta BJ, Perrone AE, Milduberger N, Bua J.
PMID: 28179991
Cell Death Discov. 2017 Feb 06;3:16092. doi: 10.1038/cddiscovery.2016.92. eCollection 2017.

Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial...

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Bustos PL, Volta BJ, Perrone AE, et al. A homolog of cyclophilin D is expressed in . Cell Death Discov. 2017;3:16092doi: 10.1038/cddiscovery.2016.92.
Bustos, P. L., Volta, B. J., Perrone, A. E., Milduberger, N., & Bua, J. (2017). A homolog of cyclophilin D is expressed in . Cell death discovery, 316092. https://doi.org/10.1038/cddiscovery.2016.92
Bustos, Patricia L, et al. "A homolog of cyclophilin D is expressed in ." Cell death discovery vol. 3 (2017): 16092. doi: https://doi.org/10.1038/cddiscovery.2016.92
Bustos PL, Volta BJ, Perrone AE, Milduberger N, Bua J. A homolog of cyclophilin D is expressed in . Cell Death Discov. 2017 Feb 06;3:16092. doi: 10.1038/cddiscovery.2016.92. eCollection 2017. PMID: 28179991; PMCID: PMC5292771.
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Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation.

Cell death discovery

Mittra I, Samant U, Sharma S, Raghuram GV, Saha T, Tidke P, Pancholi N, Gupta D, Prasannan P, Gaikwad A, Gardi N, Chaubal R, Upadhyay P, Pal K, Rane B, Shaikh A, Salunkhe S, Dutt S, Mishra PK, Khare NK, Nair NK, Dutt A.
PMID: 28580170
Cell Death Discov. 2017 May 29;3:17015. doi: 10.1038/cddiscovery.2017.15. eCollection 2017.

Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation that can lead to their oncogenic transformation. Mediator(s) of cell-cell communication that brings about these pro-oncogenic pathologies has not been identified. We show here that cell-free...

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Mittra I, Samant U, Sharma S, et al. Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation. Cell Death Discov. 2017;3:17015doi: 10.1038/cddiscovery.2017.15.
Mittra, I., Samant, U., Sharma, S., Raghuram, G. V., Saha, T., Tidke, P., Pancholi, N., Gupta, D., Prasannan, P., Gaikwad, A., Gardi, N., Chaubal, R., Upadhyay, P., Pal, K., Rane, B., Shaikh, A., Salunkhe, S., Dutt, S., Mishra, P. K., Khare, N. K., Nair, N. K., & Dutt, A. (2017). Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation. Cell death discovery, 317015. https://doi.org/10.1038/cddiscovery.2017.15
Mittra, Indraneel, et al. "Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation." Cell death discovery vol. 3 (2017): 17015. doi: https://doi.org/10.1038/cddiscovery.2017.15
Mittra I, Samant U, Sharma S, Raghuram GV, Saha T, Tidke P, Pancholi N, Gupta D, Prasannan P, Gaikwad A, Gardi N, Chaubal R, Upadhyay P, Pal K, Rane B, Shaikh A, Salunkhe S, Dutt S, Mishra PK, Khare NK, Nair NK, Dutt A. Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation. Cell Death Discov. 2017 May 29;3:17015. doi: 10.1038/cddiscovery.2017.15. eCollection 2017. PMID: 28580170; PMCID: PMC5447133.
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[No title available]

Cell death discovery

Makarev E, Schubert AD, Kanherkar RR, London N, Teka M, Ozerov I, Lezhnina K, Bedi A, Ravi R, Mehra R, Hoque MO, Sloma I, Gaykalova DA, Csoka AB, Sidransky D, Zhavoronkov A, Izumchenko E.
PMID: 28580171
Cell Death Discov. 2017 May 22;3:17022. doi: 10.1038/cddiscovery.2017.22. eCollection 2017.

A subset of patients with oral squamous cell carcinoma (OSCC), the most common subtype of head and neck squamous cell carcinoma (HNSCC), harbor dysplastic lesions (often visually identified as leukoplakia) prior to cancer diagnosis. Although evidence suggest that leukoplakia...

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Makarev E, Schubert AD, Kanherkar RR, et al. . Cell Death Discov. 2017;3:17022doi: 10.1038/cddiscovery.2017.22.
Makarev, E., Schubert, A. D., Kanherkar, R. R., London, N., Teka, M., Ozerov, I., Lezhnina, K., Bedi, A., Ravi, R., Mehra, R., Hoque, M. O., Sloma, I., Gaykalova, D. A., Csoka, A. B., Sidransky, D., Zhavoronkov, A., & Izumchenko, E. (2017). . Cell death discovery, 317022. https://doi.org/10.1038/cddiscovery.2017.22
Makarev, Eugene, et al. "." Cell death discovery vol. 3 (2017): 17022. doi: https://doi.org/10.1038/cddiscovery.2017.22
Makarev E, Schubert AD, Kanherkar RR, London N, Teka M, Ozerov I, Lezhnina K, Bedi A, Ravi R, Mehra R, Hoque MO, Sloma I, Gaykalova DA, Csoka AB, Sidransky D, Zhavoronkov A, Izumchenko E. . Cell Death Discov. 2017 May 22;3:17022. doi: 10.1038/cddiscovery.2017.22. eCollection 2017. PMID: 28580171; PMCID: PMC5439156.
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Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.

Cell death discovery

Duclos CM, Champagne A, Carrier JC, Saucier C, Lavoie CL, Denault JB.
PMID: 28179995
Cell Death Discov. 2017 Jan 23;3:16100. doi: 10.1038/cddiscovery.2016.100. eCollection 2017.

The unfolding of apoptosis involves the cleavage of hundreds of proteins by the caspase family of cysteinyl peptidases. Among those substrates are proteins involved in intracellular vesicle trafficking with a net outcome of shutting down the crucial processes governing...

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Duclos CM, Champagne A, Carrier JC, et al. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017;3:16100doi: 10.1038/cddiscovery.2016.100.
Duclos, C. M., Champagne, A., Carrier, J. C., Saucier, C., Lavoie, C. L., & Denault, J. B. (2017). Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell death discovery, 316100. https://doi.org/10.1038/cddiscovery.2016.100
Duclos, Catherine M, et al. "Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling." Cell death discovery vol. 3 (2017): 16100. doi: https://doi.org/10.1038/cddiscovery.2016.100
Duclos CM, Champagne A, Carrier JC, Saucier C, Lavoie CL, Denault JB. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017 Jan 23;3:16100. doi: 10.1038/cddiscovery.2016.100. eCollection 2017. PMID: 28179995; PMCID: PMC5253419.
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Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during .

Cell death discovery

Nag P, Aggarwal PR, Ghosh S, Narula K, Tayal R, Maheshwari N, Chakraborty N, Chakraborty S.
PMID: 29152379
Cell Death Discov. 2017 Nov 13;3:17073. doi: 10.1038/cddiscovery.2017.73. eCollection 2017.

Although precisely controlled innate immune response is governed by conserved cellular events in phylogenetically diverse hosts, the underlying molecular mechanisms by which this process is regulated against a multi-host pathogen remain unknown.

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Nag P, Aggarwal PR, Ghosh S, et al. Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during . Cell Death Discov. 2017;3:17073doi: 10.1038/cddiscovery.2017.73.
Nag, P., Aggarwal, P. R., Ghosh, S., Narula, K., Tayal, R., Maheshwari, N., Chakraborty, N., & Chakraborty, S. (2017). Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during . Cell death discovery, 317073. https://doi.org/10.1038/cddiscovery.2017.73
Nag, Papri, et al. "Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during ." Cell death discovery vol. 3 (2017): 17073. doi: https://doi.org/10.1038/cddiscovery.2017.73
Nag P, Aggarwal PR, Ghosh S, Narula K, Tayal R, Maheshwari N, Chakraborty N, Chakraborty S. Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during . Cell Death Discov. 2017 Nov 13;3:17073. doi: 10.1038/cddiscovery.2017.73. eCollection 2017. PMID: 29152379; PMCID: PMC5684781.
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Mitochondrial pharmacology turns its sights on the Ca.

Cell death discovery

Storey NM, Lambert DG.
PMID: 28955506
Cell Death Discov. 2017 Sep 25;3:17064. doi: 10.1038/cddiscovery.2017.64. eCollection 2017.

No abstract available.

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Storey NM, Lambert DG. Mitochondrial pharmacology turns its sights on the Ca. Cell Death Discov. 2017;3:17064doi: 10.1038/cddiscovery.2017.64.
Storey, N. M., & Lambert, D. G. (2017). Mitochondrial pharmacology turns its sights on the Ca. Cell death discovery, 317064. https://doi.org/10.1038/cddiscovery.2017.64
Storey, Nina M, and Lambert, David G. "Mitochondrial pharmacology turns its sights on the Ca." Cell death discovery vol. 3 (2017): 17064. doi: https://doi.org/10.1038/cddiscovery.2017.64
Storey NM, Lambert DG. Mitochondrial pharmacology turns its sights on the Ca. Cell Death Discov. 2017 Sep 25;3:17064. doi: 10.1038/cddiscovery.2017.64. eCollection 2017. PMID: 28955506; PMCID: PMC5611713.
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Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.

Cell death discovery

Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV.
PMID: 27648301
Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016.

Colon cancer is a leading cause of cancer-related mortality for which targeted therapy is needed; however, trials using apoptosis-inducing ligand monotherapy to overcome resistance to apoptosis have not shown clinical responses. Since colon cancer cells selectively uptake and rapidly...

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Carr RM, Qiao G, Qin J, et al. Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Cell Death Discov. 2016;2:16067doi: 10.1038/cddiscovery.2016.67.
Carr, R. M., Qiao, G., Qin, J., Jayaraman, S., Prabhakar, B. S., & Maker, A. V. (2016). Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Cell death discovery, 216067. https://doi.org/10.1038/cddiscovery.2016.67
Carr, Ryan M, et al. "Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis." Cell death discovery vol. 2 (2016): 16067. doi: https://doi.org/10.1038/cddiscovery.2016.67
Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV. Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016. PMID: 27648301; PMCID: PMC5018545.
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